David Sinclair talks about Gene Therapy to Reverse Glaucoma

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Aging | This Lifespan Book Will Change Your Life

In July 2020, David Sinclair was interviewed by Sam Bak-te-ar that is a medical professional, an author and was as soon as a world-class body builder.
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NAD or Nicotinamide Adenine Dinucleotide to offer it its full name is located in virtually all our living cells, NAD+ is important for sustaining life. NAD degrees decrease substantially with age, developing an energy deficit that reduces the body's ability to retain younger features. NAD is biologically unsteady, that makes it unsuitable for dental supplements. Luckily, it is easy to restore your mobile NAD levels using NMN (Nicotinamide Mononucleotide) or NR (Nicotinamide Riboside), which converts to NAD when it remains in the cell. To provide you an idea just how NAD+ decreases with age; organic studies have actually shown that by age 50 a typical person may have just half the NAD+ they carried out in young people, by age 80, NAD+ (Nicotinamide Adenine Dinucleotide) levels go down to between 1% to 10% of those shared in young people. An interesting facet of NAD+ is its dual function in securing against aspects that age us. This consists of mitigating chemical anxiety, inflammation, DNA damage, as well as failing mitochondria, all conditions related to aging. Simply put, while a decline in NAD+ levels might adversely influence life-span and Healthspan (health-span), so restoring NAD+ is significantly being deemed a clinical cutting-edge device to promote long life as well as a method to deal with the conditions old as well.
A strenuous scientific evaluation of NAD+ discloses that its longevity advantages develop from 8 various, however related, features. In 2013 a clinical research study; 2-year old computer mice were checked for muscular tissue wastefulness, insulin resistance as well as inflammation, all are, on humans made use of as indications of the aging process, they were then offered NMN (Nicotinamide Mononucleotide) for 1 week. In all situations, after just 1 week the 2-year old computer mice were mirroring the anticipated searchings for of 6-month old computer mice in the locations of muscle wastage, insulin resistance and also inflammation. In human terms that would approach a 75-year old having the results you would certainly expect from a 25-year old. In a later systematic research study, in 2018, again on computer mice, Dr. David Sinclair's team at the Harvard Medical Institution found that the aging of blood vessels had actually been turned around. The scientific research revealed that computer mice that were provided NMN (Nicotinamide Mononucleotide) had actually recovered capillary development as well as had boosted muscle endurance by up to 80%.
NMN is the pre-cursor to NAD+ (Nicotinamide Adenine Dinucleotide), so what you may say? NAD+ is utilized to power out metabolic rate, at the simplest degree, it turns our food right into power. By raising NAD with NMN or NR (Nicotinamide Riboside) we can commence those genes once more and also get them to decrease the aging procedure; maybe even reverse it.
Supplements with NMN (Nicotinamide Mononucleotide) and NR (Nicotinamide Riboside) has been shown to slow mobile aging in mice as well as enhance lots of metabolic problems usual to degenerative procedures, including muscle waste, insulin resistance as well as swelling. Nicotinamide mononucleotide (" NMN", "NAMN", as well as "β-NMN") is a nucleotide stemmed from ribose and nicotinamide. Like nicotinamide riboside, NMN is a by-product of niacin and also human beings have enzymes that can utilize NMN to produce nicotinamide adenine dinucleotide (NADH). In mice, NMN enters cells through the little intestines within 10 mins converting to NAD+ via the Slc12a8 NMN carrier.

#NMN #LiveLonger #DavidSinclair.

Acknowledgments:.
Video: Pexels, Oscar Due Wang.
Sound: Mrs. Zazzara by Loxbeats Creative Commons– Acknowledgment 3.0 Unported– CC BY 3.0 Music advertised by Audio Collection.
PLEASE NOTE: This video clip and also summary includes a discount rate code, which implies that if you utilize the code, I will obtain a little compensation. Additionally, although they do not really pay me, DoNotAge.org has actually sent me totally free products by way of sponsorship.

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LIFESPAN Book by David Sinclair: Aging & Aging-Related Diseases

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Aging | This Lifespan Book Will Change Your Life

Examination, do not think. The initial step to a healthier you is to recognize first the standing of your wellness. Look into the "Got Sugar?" Webinar New Year Unique here: Intend to find out among the basics of cardiac arrest & stroke avoidance … totally free? Break out accessibility to the Curriculum Vitae inflammation program by finishing this type: Learn just how to predict & protect against cardiac arrest & stroke:

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— REGARDING THIS VIDEO CLIP: I'm covering David Sinclair's new book, "Lifespan: Why We Age– and Why We Do not Have To." Included here are some intriguing theories and also discussions about aging as well as age-related diseases.

I additionally discussed the topics of Valter Longo's Prolon FMD (not eating mimicking diet regimen), vitamin K2 carboxylation and vitamin K2-dependent enzymes, inflammation tests (Hs-CRP, MPO, Lp-PLA2, and MACR), secret life of fat cells, and also niacin.

ENROLLMENT IS NOW OPEN!!!
Heart Attack and Stroke Prevention Meeting on Nov 8-9, 2019 in Louisville, KY. Register Now!!!

Membership Location Enrollment Web Link -CONCERNING DR. MAKER: Dr. Brewer began as an Emergency situation Doctor. After seeing way too many preventable heart attacks, he went to Johns Hopkins to discover Preventive Medication. While there, he went on the run the post-graduate training program (residency) in Preventive Medicine. From there, he made a profession of exercising as well as handling preventative medication and also primary care facilities. His later duty in this field was Principal Medical Policeman for Premise, which has near to 1,000 key care/prevention facilities. He was additionally the Principal Medical Officer for MDLIVE, the 2nd biggest telemedicine company. Extra just recently, he established PrevMed, a cardiovascular disease and also stroke prevention facility.

At PrevMed, we focus on cardiac arrest, stroke, and cognitive decrease. We serve patients who have already experienced an occasion along with those who have not created a medical diagnosis or occasion. Dr. Brewer supplies solutions through telemedicine or personally if you remain in the Lexington, KY location. We find a lot of undiagnosed prediabetes or insulin resistance. Treating unknown danger factors like prediabetes enables reduction of threat and also avoidance of disease.

If you are interested in coming to be an individual, please see our website: You can likewise follow us on various social media websites: Facebook: Instagram: Pinterest: Twitter: LinkedIn: Assistance us in our cause to spread recognition of preventive medicine and stop the major reasons of death and disability. Join us on Patreon: Get a High-Quality CIMT in a city near you! Register at CardioRisk.US/ Ford () Products stated are offered through these Amazon.com Partner links.
Vitamin D3: Citrulline: Enduracin: Omega 3 oil (EPA):.
Freestyle Lite Glucometer:.
Freestyle Lite Examination Strips:.
Beat the Cardiac Arrest Gene:.

TRANSLATIONS *** Please aid by providing translation of video subtitles for those that speak your language. Not every person understands English, particularly with my Southern United States drawl. Click this web link to offer translation solutions – conserve lives !!

PREVMED OCCASION: Cardiovascular Disease and Stroke Prevention Seminar on Nov 8-9, 2019 in Louisville, KY. Learn more as well as register for the occasion right here:.

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David Sinclair’s Dad’s Supplement & Workout Regime

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Aging | This Lifespan Book Will Change Your Life

In most of his talks and also interviews David Sinclair typically speaks about his father Andrew Sinclair as well as how in shape he is. So, if you are interested what his 80-year old dad does, when it come to diet plan, exercise and also supplements, keep seeing.

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DoNotAge.org Store:

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– So, David Sinclair clarifies that he is frequently amazed by people who admit they don't intend to live longer than 80 years old, why?
– He proffers, because they have actually seen what many 80-year old's look like, and also to them, it is not appealing
– Andrew Sinclair, David's Father, does nonetheless show that 80 isn't completion … vice versa
Andrew Sinclair claims has no persistence for those who state your health-span is pre-determined
At 80, he states, he has no memory problems, no pains, no discomforts as well as no depression
He claims, that today, he feels the way he did when he was 30 or 40.
– Not a scientific Trial. David Sinclair says, 'this isn't a scientific trial and the response is NOT just in one molecule.'
– Effect. Yes, my papa takes NMN, metformin and a little resveratrol, however there is still no other way to understand what impact those medications and also supplements are having on him
– Evidence. We need much more scientific evidence with double-blind placebo controls on dozens, if not hundreds, of people his age as well as from his demographic
– Job principles. And, also if the particles he is taking are helping, it would be very rude not to note the incredible FUNCTION father has actually taken into staying healthy and balanced, says David
– Duration: "I generally exercise twice a week for 70 to 90 minutes. So, between and also hour and a hr as well as a fifty percent; is that achievable for you?
– Warm-up. I begin with warming up on the rowing maker for 15
minutes, dealing with 2,500 meters, followed by stretches and then weights
Weightlifting. He does 3 sets of each exercise with 10 reps at the complying with weights:
– Bench presses: 40 kg (88 pounds).
– Leg presses: 130 kg (286 pounds).
– Belly curls: 50 kg (110 pounds).
– Peck-deck: 40 kg (88 lbs).
– Deadlift: 50 kg (110 pounds).
– Knee-ups: 50 kg (110 pounds).
– Versatility. He likewise does Pilates for an hour every week to help with flexibility and also strolls from 5 to 7 kilometers (that around 3.1 to 4.3 miles) on most days. So, another hour a week on Pilates as well as 5 to 7 k's a day walking (that's mosting likely to go to the very least 1 hr a day, this is currently beginning to accumulate and may not be possible for individuals ho work or who have young households, I'm thinking he doesn't walk or do Pilates on the days he does weight training, to make sure that is one hour everyday, could you commit an hour a day to work out? I currently it's simple to claim yes, yet if you work and have a young family, 1 hour everyday may not be achievable?
– Stair Climber/Step Machine. "In some cases I stroll on a staircase climber," he included. "My current record is 40 floors in less 15 mins. It almost eliminated me, but I did it.".
– Relaxing Heart Rate. His resting heart rate is simply below 60 beats per minute.
– Maximum Heart Rate. His maximum heart rate should be 220 minus his age of 80. That = 140 beats per min.
– Actual performance. On the step maker it was 155 beats per min, much above what his max should be.
– "I talked to my medical professional," Andrew discussed. "She said if you can do it, after that do it.– So, I did!" he stated.
Of course, exercise alone doesn't keep anybody healthy, let alone a person that is 80, so my daddy sees what he consumes, as well.
– Unhealthy food. No convenience food, simple I intend … None!
– House Cooked. All home-cooked or healthy restaurant-cooked dishes.
Lots of veggies with a little hen or seafood and on more rare events beef. He has a tiny breakfast of cereal as well as often skips lunch since he's also active repainting your home or something.
– Drinks. I think he indicates alcohol, where David Sinclair says 'He consumes alcohol, however not a great deal. A couple of times a week, that's all and not to extra. No sugary soft drinks, which I intend can likewise be detailed under processed food.
– Dessert. He'll have a pleasant (I presume he suggests treat or pudding) from time to time, however doesn't overdo that either.
– Fruit. "I likewise eat lots of fruit, but do not drink adequate water, though I'm attempting to drink even more," said Andrew.

#antiaging #NAD+ #DavidSinclair.
Recommendations:.
Video: Pexels, Oscar Fee Wang.
Sound: Mrs. Zazzara by Loxbeats Creative Commons– Attribution 3.0 Unported– CC BY 3.0 Songs advertised by Audio Library.
PLEASE NOTE: This video and summary includes a discount code, which suggests that if you make use of the code, I will certainly obtain a small compensation.
Likewise, although they don't actually pay me, DoNotAge.org has sent me cost-free products to show on this video.

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David Sinclair compilation video on Anti-Aging.

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Aging | This Lifespan Book Will Change Your Life

This is a pressed compilation of video lectures of David Sinclair on anti-aging. It clarifies info about NMN, Resveratrol, and Sirtuins.

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NAD+ in Aging: Role of Nicotinamide Riboside and Nicotinamide Mononucleotide

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Aging | This Lifespan Book Will Change Your Life

NAD+ in Aging: Role of Nicotinamide Riboside and Nicotinamide Mononucleotide

In this episode, Rhonda explains what NAD+, why it is so essential for maturing as well as why it declines with age. She goes over several of the popular NAD+ boosters like nicotinamide riboside as well as nicotinamide mononucleotide, what pet and human information says and some ending ideas.

NAD+ is important for our survival. Percentages of it can be acquired in the diet regimen, however the body reuses it to obtain most of what it needs. However, everyday living plus regular aging can trigger NAD+ levels to drop. This creates metabolic and mitochondrial disorder, in addition to a number of the various other issues and also problems connected with maturing like elevated DNA damages. NAD+ levels can increase when we exercise or quick, but NAD+ precursors like nicotinamide riboside and also nicotinamide mononucleotide can additionally boost NAD+ degrees in a dose-dependent manner. Nevertheless, most of the data on NAD+ boosters comes from pet research studies. Whether these boosters are effective– and also secure– lasting in people is still a huge concern.

▶ Get the episode’s show notes, timeline, and also more

▶ In-depth overview of NAD+.

▶ Detailed summary of nicotinamide riboside.

▶ In-depth review of nicotinamide mononucleotide.

▶ Did you enjoy this podcast? If you intend to support me in obtaining even more of this free details bent on the public, please take into consideration coming to be an FMF premium member! In doing so, you’ll additionally get accessibility to special participant benefits, such as a private podcast feed offering early accessibility and also occasional benefit episodes, month-to-month live Q&A s with me, a members-only library that includes discussion slides with every one of the sustaining numbers, graphics, referrals, as well as quotes. Likewise consisted of are Rhonda’s exclusive notes on topics talked about in the podcast, bi-monthly member-exclusive Science Information Digest email, and much more. Thank you for your factor to consider! Discover more below:.

▶ Gain important understandings by running your raw hereditary data with the FoundMyFitness report.

nad+ precursor nicotinamide mononucleotide

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NMN & Resveratrol Follow up & New Experiment Plan

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The Plant Paradox

In this video I explain what I discovered after reading David Sinclair's book and looking into the anti-aging subject extra. I clarify just how I plan to run my next experiment in an attempt to locate information that shows these particles are slowing my all-natural again procedure.
Video Clip Time Line:
Introduction (why I made this video) 0:00 – 1:04
Addressing the comments 1:04–.
Quick please note 1:50– 2:20.
Why Horvath examination is finest method to measure 2:20– 4:07.
Why I was wrong last time about it 3:34– 4:07.
1 gram or 1/2 gram of Resveratrol confusion 4:07– 5:31.
Taking Resveratrol with yogurt? 5:37– 6:13.
Where do you get the NMN 6:13– 7:06.
Why does Sinclair take 3 anti-aging medications? 7:06– 7:56.
Metformin 7:56 – 10:53.
Resveratrol 10:53– 12:30.
NMN 12:30– 16:36.
Why NMN rather than NR? 14:03– 15:12.
Should you take NMN sublingually? 15:12– 16:32.
How I will certainly take NMN 16:17– 16:32.
Do these medication operate in human beings or just computer mice? 16:36– 17:23.
Sinclair's Daddy and my similar liver enzymes results 17:23 – 18:34.
Instance of why Horvath test is superior 18:34– 19:05.
Scientist stating why my next test is finest I can do 19:05– 20:02.
My Next anti-aging trying out NMN 20:02– 22:29.
How much time should I wait in-between test? 20:16– 20:56.
Final thought 20:56– 28:17.
How I am going to pay the $2,000 to do this 23:01– 24:48.
Made a playlist as well as will put all info on an internet site 24:48– 26:11.
The Sugar pill effect possibility 26:11– 27:07.
My next video clip will be Horvath examination results 27:36– 28:17.

Peter Attia & David Sinclair Podcast:.

Here are the amazon web links to the products I am taking:.
NMN:.

Resveratrol:.

Link to the part 1 of my very first experiment:.

Web link to the part 2 of my initial experiment:.

Web link to the part 3 of my first experiment:.

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Dr. David Sinclair on Informational Theory of Aging, Nicotinamide Mononucleotide, Resveratrol & More

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The Plant Paradox

David A. Sinclair, PhD, is a professor in the Division of Genes at Harvard Medical Institution and co-director of the Paul F. Glenn Facility for the Organic Mechanisms of Aging.

Dr. Sinclair's work focuses on comprehending the mechanisms that drive human aging as well as recognizing methods to reduce or turn around aging's impacts. Particularly, he has examined the duty of sirtuins in disease as well as aging, with unique focus on exactly how sirtuin activity is regulated by substances produced by the body in addition to those eaten in the diet plan, such as resveratrol. His job has ramifications for human metabolism, mitochondrial as well as neurological health, and also cancer.

▶ Get the episode's program notes, timeline, as well as transcript.

▶ Detailed summary of NAD+.

▶ Thorough summary of nicotinamide riboside.

▶ In-depth subject page on nicotinamide mononucleotide.

▶ Adhere To Dr. David Sinclair on Twitter.

▶ BOOK: Life expectancy: Why We Age and Why We Don't Need to.

▶ Go To the Sinclair Laboratory.

▶ Did you enjoy this podcast? If you want to sustain me in getting more of this totally free info out to the public, please take into consideration becoming an FMF costs member! In doing so, you'll additionally obtain access to unique participant benefits, such as a personal podcast feed offering early accessibility and occasional incentive episodes, monthly live Q&A s with me, a members-only library that includes presentation slides with all of the supporting numbers, graphics, recommendations, and also quotes. Also consisted of are Rhonda's personal notes on subjects talked about in the podcast, bi-monthly member-exclusive Science News Digest e-mail, and more. Thank you for your consideration! Find out more here:.

▶ Send your raw genetic information. You can discover the Sirtuin SNP report at:.

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Anti-Aging Experiment CONCLUSION + I SHAVE My HEAD!

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Aging | This Lifespan Book Will Change Your Life

Today on Lex’s Lounge we end our Anti-Aging experiment after concerning 4 months, influenced by David Sinclair. The supplements he recommends taking are listed below:

Vitamins D & K2 in one: Vitamin K2 + D3 with Organic Coconut Oil for Better Absorption
Resveratrol: Resveratrol 1400mg 120 Capsules High Potency
NR: TRU NIAGEN Nicotinamide Riboside

Nicotinamide Mononucleotide (NMN) & Resveratrol

Pure NMN (this things is pricey, NR is more affordable, but it’s a pre-cursor … it’s also notable that Dr.Sinclair takes 1000 mg of NMN himself, which ‘d be a lot more expensive).

Book Lifespan By David Sinclair

nad+ precursor nicotinamide mononucleotide

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3 Factors to Consider When Buying NMN

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Aging | This Lifespan Book Will Change Your Life

 

NMN Forum:
forums.sourcesupps.com

So, two concerns that turn up time and time again are where to purchase NMN from and also can I suggest a distributor?

Undoubtedly, I can’t recommend just one, yet I can reveal you a few of the things to think about when picking your distributor and some points I have seen when browsing NMN vendor internet sites that have actually triggered me some worry.

Please, if there are any kind of various other factors that ought to be thought about, in your viewpoint, please create them listed below so everybody can profit.

So thankfully, it’s a PowerPoint presentation, so say goodbye to of my unsightly mug, allow’s obtain straight right into it.

NMN is the pre-cursor to NAD+, so what you may state?

Well NAD+ is utilized to power out metabolism; merely it turns our food into power.

NAD+ is also in charge of regulating the genetics that power the aging process, as we grow older our NAD levels drop so the aging genetics are permitted to continue untreated; ergo we age, the reduced the levels the quicker we age. Dr. David Sinclair claims that research has revealed that by the time we are 50 we have FIFTY PERCENT the degrees we did when were 20! By increasing NAD via NMN we can kick-start those genes once again as well as get them to decrease the aging process.

Book Lifespan By David Sinclair

nad+ precursor nicotinamide mononucleotide

More about NAD + Precursor Nicotinamide Mononucleotide

Nicotinamide Mononucleotide (NMN) & Resveratrol

#antiaging #NAD+ #longevity

Acknowledgments:
Video clip: Pexels, Oscar Fee Wang
Audio: Mrs. Zazzara by Loxbeats Creative Commons– Acknowledgment 3.0 Unported– CC BY 3.0 Songs advertised by Sound Collection

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NMN (Nicotinamide Mononucleotide); Day 60 Update

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The Plant Paradox

So, today I will review my 2 month or 60-day results, I will certainly compare the data I videotaped in April with the information I recorded 60 days later.
Throughout the video clip I will certainly likewise be asking you for some guidance, I am looking at another approach for determining certain markers and also taping my progress.

I would be really appreciative of any type of feedback.

PLEASE LIKE As Well As SUBSCRIBE FOR MORE FROM MY NMN CHANNEL

Promptly before I review my results I would certainly to upgrade my searchings for on the food grade v pharmaceutical grade video clip. My initial understanding from my research was that makers originally produced Pharama Grade NMN and after that add safe fillers etc. at any quantity they liked to boost flow right into pills or for visual effect.

It appears, and also lots of thanks to ‘Biohaxxter’ who is also taking NMN for some additional Information; that food grade is created which in itself can be as much as 98+% pure as well as this after that goes through various other process to make it also purer (this is done due to the fact that the highest possible Pharma quality is needed for research studies).

This is true for food grade NMN powder, however not capsules as they still need filler, in whatever amount the supplier regards ideal, to load the pill or improve circulation through the tableting devices. So, many thanks once more to Biohaxxter!

So, my results – I have gotten my NMN from China and also as soon as I end up these pills, I will certainly increase to 500mg a day of powder; I will do 2 months sublingually (under the tongue) and after that I might transform to blending it in with water for 2 months to see if there are any kind of substantial changes.

Why would I do this? Several many thanks to Leslie that commented on my last video clip as well as in fact e-mailed David Sinclair and obtained a reply; he created ‘Sublingual is not needed in medical trials. Capsules function great for increasing NAD’.

I understand that may throw Swiss-Trader as well as Alive by Nature into a flat-spin; they are strong advocates of Sublingual management; if it’s excellent sufficient for Sinclair, adequate for me!

So, now my demand, did my organic age truly boost by 3 years, even if I didn’t as much exercise for the month of Ramadan?

I am likewise considering utilizing an extra scientific means (than my fitness center analysis maker) to measure my biological age and so on as well as evaluate what, if any type of, result my NMN experiment is having on it. It will certainly be costly, yet I assume the degree of evaluation on my biological age etc. will certainly be worth the expenditure.

I am looking into a business called Within Tracker, has any person utilized it or something like it? Can you advise it or one more company?

If you have the time, take a look at their internet site and also see if you assume it would be a great concept for me, additionally let me recognize if it might be something you would certainly think about doing also.

Please allow me understand if you believe is a great suggestion, I’m unsure that my biological age has enhanced by 3 years even if I did much less exercise for 1 month?

Nicotinamide Mononucleotide (NMN) & Resveratrol

#antiaging #NAD+ #longevity

Acknowledgments:
Video: Pexels, Oscar Fee Wang
Sound: Mrs. Zazzara by Loxbeats Creative Commons– Attribution 3.0 Unported– CC BY 3.0 Music advertised by Sound Library

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