NAD+ is a substrate for the sirtuin proteins, a family members of enzymes involved in a selection of metabolic processes. Sirtuins make use of NAD+ to get rid of specific chemical frameworks called acetyl groups– a procedure called deacetylation– from mobile proteins to control transcriptional law, basal metabolism, body clocks, DNA fixing, as well as cell survival. In a straightforward example, NAD+ is the gas in a car that the sirtuins are driving. To bring that example a bit more, resveratrol, a plant-based particle discovered in red grapes as well as peanuts, serves as an accelerator to boost the activity of the fuel– NAD+. In this clip, Dr. David Sinclair explains the links in between NAD+, sirtuins, and also resveratrol in the aging process.
This clip was taken from the FoundMyFitness interview with Dr. David Sinclair found at https://youtu.be/5DtWqzalEnc
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Original episode released on Nov 6, 2019